Abstract 12761: Incidence and Prevalence of Peripheral Artery Disease and Critical Limb Ischemia in an Insured National Population
Context: Critical limb ischemia (CLI) represents the most severe clinical manifestation of peripheral artery disease (PAD) and is the major cause of ischemic amputation in the United States. CLI is also known to be associated with high rates of myocardial infarction and stroke. However, while PAD incidence and prevalence are known, the incidence and prevalence of CLI has not been measured in the contemporary United States population.
Objective: To estimate the annual incidence and prevalence of PAD and CLI and to describe the baseline demographics and co-morbidities in a representative United States cohort defined by a commercial, Medicare, and Medicaid administrative claims database.
Design, Setting, and Patients: Retrospective cohort analysis of adults ≥ 40 years with commercial, Medicare supplemental, or Medicaid health insurance, and who had one or more PAD or CLI healthcare claims from January 1, 2003 through December 31, 2008.
Main Outcome Measures: Annual incidence and prevalence of PAD and CLI and baseline demographics and co-morbidities for each year from 2003 through 2008, stratified by health care plan.
Results: A total of 263,270 eligible individuals with a PAD diagnosis code and 44,431 patients with a CLI diagnosis code were identified during the study period, with a mean age of 68.9 (95% CI 68.8 - 68.9). The average annual incidence and prevalence of PAD, calculated each year from 2003-2008 was 2.76% (95% CI 2.75 - 2.77) and 12.29% (95% CI 12.28 - 12.31), respectively, and was higher in the combined Medicare and Medicaid populations than in the commercial population. The average annual incidence and prevalence of CLI in the eligible population at risk was estimated to be 0.47% (95% CI 0.46 - 0.47) and 1.90% (95% CI 1.89 - 1.91), respectively.
Conclusions: These data establish new estimates of incidence and prevalence for PAD and the first incidence and prevalence estimates for CLI within a very large contemporary United States insured population cohort.
- Peripheral arterial disease
- Epidemiologic methods
- Healthcare delivery systems
- Population science
- © 2012 by American Heart Association, Inc.