Abstract 12277: Differences in Prevalence of Peripheral Vascular Disease: An age-sex interaction
Background: Increased chronological age is a well-known risk factor for peripheral vascular disease (PVD). Whether the relationship between age and PVD differs by sex in different vascular territories remains uncertain.
Methods: We analyzed data from 3.6 million participants (2.3 million women and 1.3 million men) between 40-100 years of age (mean of 64.1) who underwent PVD screening in the Life Line Screening Program from 2003-2008. All subjects completed a medical and lifestyle questionnaire and were evaluated by ultrasound imaging for internal carotid artery >50% stenosis (CAS), ankle brachial indices <0.9 for the detection of peripheral artery disease (PAD), and ultrasound imaging for abdominal aortic aneurysm >3cm (AAA). Association between age and outcome was identified using multivariate logistic regression analysis.
Results: The prevalence of PVD increased with increased chronological age in both women and men (Figure). A significant age - sex interaction was noted for CAS (p<0.0001). Among subjects 40-50, women were more likely to have CAS than men (0.96% vs 0.76%). However in subjects older than 50, women were less likely to have CAS than men (51-60: 1.76% vs 1.86%; 61-70: 3.56% vs 4.34%; 71-80: 6.08% vs 7.93%; 81-90: 8.48% vs 12.01%; 91-100: 10.60% vs 12.82%; p<0.001 for each comparison). While PAD was more frequent in women than men across every age decile, AAA was more frequent in men than women regardless of age group.
Conclusion: In a self-referred screening population, the prevalence of CAS between women and men differed according to age category. Regardless of age, PAD is more common in women and AAA is more common in men. Future studies aimed at understanding these differences are needed.
- © 2012 by American Heart Association, Inc.