Abstract 12136: Relation between Oscillatory Ventilation and Cardiopulmonary Function during Exercise

Abstract

Background: Oscillatory breathing, alternating between hyperpnea and hypopnea, has been recognized in cardiac patients, especially in those with heart failure. We evaluated whether the cycle length and amplitude of oscillatory breathing correlate with the impaired cardiopulmonary function during exercise.

Methods: We analyzed respiratory gas data during cardiopulmonary exercise testing (CPX) in 17 cardiac patients (68±12 years) who showed clear oscillatory ventilation during CPX. The cycle length (time from peak to peak) and the amplitude (difference between peak and nadir) for both the oscillating ventilation (VE) and oscillating O2 uptake (VO2) were calculated from several consecutive oscillations noted at rest before the start of exercise, and compared with indices of CPX.

Results: Oscillating VO2 preceded oscillating VE in 16 out of 17 patients. Peak VO2 (10.3±3.1 mL/min/kg) correlated significantly negatively with the cycle length of the VE oscillation (r=-0.60, p=0.010), and of the VO2 oscillation (r=-0.61, p=0.008), and the difference in time between the peak of oscillating VE and the corresponding peak of VO2 (r=-0.58, p=0.012). Thus, there was a longer cycle length of VE and VO2 and a longer time difference between oscillating VE and VO2 in patients with a lower peak VO2. Similarly, the slope of the increase in VE to the increase in CO2 output (45.6±11.5) correlated significantly positively with the cycle length of the VE and VO2 oscillations (r=0.68, p=0.002; r=0.67, p=0.003, respectively).

Conclusion: The present findings suggest that the cycle length of oscillatory breathing is closely related to impaired cardiac reserve during exercise in cardiac patients.