Abstract 11969: Assessment of Left Ventricular Volumes and Ejection Fraction Using Speckle Tracking Echocardiography Avoids Time Consuming Manual Off-line Analysis: The CARDIA Study

Abstract

Background: The current method of measuring LV volumes by 2D echocardiography requires manual endocardial delineation. We applied a speckle tracking echocardiography (STE) tool to obtain left ventricular (LV) volumetric measures. This algorithm extracts information on LV volumes and ejection fraction (EF) from the same contours used for STE analysis, and compares these to standard measurements in a large cohort study.

Methods: The Coronary Artery Risk Development in Young Adults (CARDIA) study is a prospective study that enrolled 5,115 African-American and White adults (18-30 years) from 4 US centers in 1985-1986. We included participants at follow up Year-25 with STE and standard echocardiography assessment simultaneously (Toshiba Medical Systems). A novel software solution automatically extracted LV volumes and EF using STE contours. Standard LV measurements followed the American Society of Echocardiography recommendations assessing 2D 4 -chamber volumes and EF. Paired t-test and Pearson correlation were used to compare STE-derived and standard echocardiography measurements.

Results: 1,939 participants were included, 50±4 years, 45% males, and 53% White. Comparing standard and STE-derived measurements, differences in mean values for EDV, ESV and EF were approximately one standard deviation for both methods. A good correlation was found between 2D STE and standard echocardiography, with fair limits of agreement within methods(Table).

Conclusions: The new algorithm of STE does not require manual endocardial delineation and conforms with the standard method for LV volumes and EF in a large cohort study. The ability to extract accurate standard volumetric measurements from STE analysis avoids time consuming manual off-line analysis.