Abstract 11836: Deceleration Time of Early Diastolic Velocity of Mitral Annulus by Tissue Doppler Image: A Novel Index of Left Ventricular End-diastolic Pressure

Abstract

PURPOSE: This study aimed to examine the diagnostic utility of the deceleration time (DT) of early diastolic velocity of mitral annulus by tissue Doppler velocity image, a method for the assessment of left ventricular end-diastolic pressure (LVEDP).

METHODS: Simultaneous LV catheterization and Doppler echocardiography were performed to compare DT and LVEDP in 84 patients, who were admitted to our hospital for the assessment of heart disease including cardiomyopathy (n=35), and coronary artery disease (n=49). We excluded the patients with atrial fibrillation and mitral valvular disease. Color-coded tissue Doppler images were acquired at apical 4 chamber view, and DT of early diastolic velocity measured at mitral annulus were measured. DT was also evaluated in 10 healthy subjects.

RESULTS: DT is successfully measured in all the subjects. The patients with elevated LVEDP (>18mmHg) showed shorter DT (70±18ms, n=27) compared to those with LVEDP≤18mmHg (113±20ms, n=57) and healthy subjects (112±12ms). DT was inversely proportional to LVEDP (r=0.7, p<0.0001). With a cut-off value of DT 86ms which was determined by receiver operating characteristic curve, the sensitivity and specificity of DT to detect elevated LVEDP were 95 and 93%, respectively.

CONCLUSIONS : DT of early diastolic velocity of mitral annulus could be an efficient novel index of LV end-diastolic pressure.