Abstract 11489: Coffee Consumption Affects the Impact of Weight Loss over a One-Year Period on Lipid Metabolism

Abstract

Objective: There remains a controversy over whether coffee consumption is favorable for lipid metabolism and future cardiovascular risks. We investigated the association between body mass index (BMI) and lipid parameters according to coffee consumption in the analysis of both a single-year basis and annual changes.

Methods: We enrolled 5973 individuals (3782 men; mean age 58.7 ± 10.5 years) who underwent general health screening for the analysis of a single-year basis. Among them, 4649 (77.8%) individuals had a habit of drinking coffee. A total of 1268 individuals (829 men) underwent health screening two years running.

Results: In the analysis of a single-year basis, BMI did not significantly differ according to coffee consumption in either gender. Serum levels of high-density lipoprotein cholesterol (HDL-C) (74 mg/dL) and triglycerides (TG) (75 mg/dL) in coffee drinkers were significantly higher and lower, respectively, than in non-drinkers (HDL-C, 70 mg/dL, P<0.001; TG, 81 mg/dL, P=0.011) among women with the lowest BMI quartile (< 20.9 kg/m²). On the other hand, these parameters did not significantly differ between coffee drinkers and non-drinkers in either gender among individuals with the highest BMI quartile (≥ 25.0 kg/m²). In the analysis of annual changes, percent changes in BMI (%dBMI) were associated with percent changes in HDL-C in the 976 coffee drinkers (r=-0.213, P<0.001), but not in the 292 non-drinkers (r=0.001, P=NS). %dBMI was significantly related with percent changes in TG (%dTG) in both coffee drinkers (r=0.272, P<0.001) and non-drinkers (r=0.187, P=0.001). In linear regression analysis, the β value of %dBMI for %dTG was significantly higher in coffee drinkers (β=3.45) than in non-drinkers (β=1.89, P=0.029).

Conclusions: Over a one-year period, a reduction in BMI had a greater impact on changes in HDL-C and TG in coffee drinkers than in non-drinkers. Our findings suggest that coffee consumption may have a favorable effect on lipid metabolism.