Abstract 11249: Colchicine Can Reduce Early Recurrence of Atrial Fibrillation after Pulmonary Vein Isolation
Background: Early recurrence of atrial fibrillation (AF) after pulmonary vein isolation (PVI) was closely related with an acute inflammatory process including high body temperature, increased high-sensitive C-reactive protein (hs-CRP) and presence of signs of pericarditis. It was reported that colchicine reduced the incidence of postoperative atrial fibrillation after cardiac surgery without complications. In this study, we investigated whether colchicine prevent early recurrence of AF after single PVI.
Methods: We studied 33 patients (mean age: 64±7 years, 18 males) who underwent single PVI for paroxysmal AF. Subjects were assigned to colchicine group (n=13) and control group (n=20) randomly. In colchicine group, patients were treated with a maintenance dose of 0.5 mg once daily for 2 weeks after PVI. No patients received anti-arrhythmic drug after PVI. The study endpoint was defined as the incidence of AF lasting > 30 sec within 2 weeks following AF ablation. Inflammatory parameters including pre-ablation hs-CRP, hs-CRP at 2weeks after PVI, max body temperature after PVI and body temperature at discharge were comparable between the two groups.
Results: In colchicine group, hs-CRP at discharge and the incidence of AF within two weeks after PVI was significantly lower than in the control group. (0.88±0.80 vs. 1.77±1.29, p=0.031, 8% vs. 40%, p=0.047, respectively) (table)
Conclusion: Colchicine could improve inflammatory process after PVI and reduce the incidences of AF within 2 weeks after PVI.
- © 2012 by American Heart Association, Inc.