Abstract 11171: Observation of Recovery of Flow-mediate Vasodilatation After Repetitive Measurements- Comparisons With Physiological Indices of Vascular Function
In repetitive measurement of flow-mediated vascular dilatation (FMD), the reproductively is assumed after an adequate interval up to 15min, but it has not been adequately investigated. We examined FMD recovery followed by sequential repetitive measurement, and hypothesized that reduced recovery in an earlier period would be altered according to residual vascular function, which correlates with an early vascular impairment. Thirty healthy male (40.8±11 years old) volunteer were enrolled, and underwent blood sampling, carotid sonography and cardio-ankle vascular index (CAVI). The abnormal values of blood pressure, BMI, serum lipid profile, and intimal thickening were not detected in the enrolled subjects. Rate of changes in the radial artery diameter in conditions of locally decreased and increased shear stress was observed (respectively, low-flow-mediated constriction [L-FMC] and flow-mediated dilation [FMD]) at the sequential time points of 0, 15, and 60min. Further recovery rate of flow-mediated total dilation (FMTD; L-FMC+ FMD) after 15min (FMTD15) was calculated as FMTD-R. FMD15, L-FMC15, and FMTD15 were significantly reduced compared to the first measurements, and all the indices were restored after 60min in all the subjects (Fig. A,B, and C). In univariate analysis, FMTD-R significantly correlated with CAVI (R2=0.23, p<0.007) and L-FMC0 (R2=0.14, p<0.05) levels. To be divided according to FMTD-R, the lower group [poor recovery group; below median value (-26.2%)] showed significantly higher CAVI values compared to the higher group (good recovery group) (Fig. D. 7.28 ± 0.60 v.s. 6.89 ± 0.44, p<0.05). In conclusion, FMD recovery requires up to 60 min and its decline in a short period would be involved in early vascular impairment.
- © 2012 by American Heart Association, Inc.