Abstract 11113: Quality of Life in Patients with Symptomatic Multivessel Coronary Artery Disease: Ten-Year Follow-Up of a Comparative Post Hoc Analyses of Medical, Angioplasty or Surgical Strategies-MASS II Trial
Background: Although clinical benefits of coronary interventions seem to be confirmed, their effects on quality of life (QoL) are still scarcely studied. We evaluated the impact of CABG, PCI or Medical Therapy (MT) on self-perceived QoL among stable CAD patients.
Methods: The Short-Form Health Survey (SF-36 QoL) was applied at baseline, 6 and 12 months and annually up to ten years. The analysis was made at baseline, 5 and 10 years. The questionnaire was administered to 611 patients randomized to 3 treatment options. After 5 years, 401 patients answered the questionnaire, and after 10 years, 334 completed the questionnaire. Of these, 110 were initially assigned to CABG, 126 to PCI, and 98 to MT. Multiple comparisons were carried out. The means of the study groups were evaluated by analysis of variance (ANOVA) and multiple comparisons were performed. The data was presented by dimensions and also separated in mental and physical parameters.
Results: In this sample, 148 patients (47.3%) had AMI, 97 (25.9%) underwent CABG or PCI, 16 (4.8%) had stroke, and 293 (87%) had angina. At baseline, the physical component of CABG patients presented the worst condition compared with PCI or MT. Regarding the mental component, there was no statistical difference between treatment groups at baseline, five and ten years P=0.157, P=0.416 e P= 0.438 respectively. On the other hand, in MT patients they scored in the mental component 63, 75 and 78, and in the physical component 54, 73 and 72, respectively at baseline, five and ten years. In CABG patients, the mental component was 59, 79 and 74, and in the physical component 46, 77 and 69, respectively. In the PCI arm, the mental component scored 64, 68 and 76 and in the physical component scored 57, 71 and 77, at baseline, five and ten years.
Conclusion: Improvement was observed in all dimensions and in the 3 therapeutic options in 5 years and that persisted in 10 years. Comparatively, CABG provided a better QoL in the first 5 years and that persisted in a 10-year follow-up.
- © 2012 by American Heart Association, Inc.