Abstract 11065: Association of Lipids with Incident Heart Failure among Adults with and Without Diabetes: The Multi-Ethnic Study of Atherosclerosis

Abstract

Background. Dyslipidemia is a risk factor for coronary disease, but its role in the development of heart failure (HF) is less well defined. The coexistence of lipid and glucose abnormalities accelerates the progression to cellular dysfunction, and may further increase the risk of incident HF. We evaluated associations of lipid fractions with incident HF in diabetic and non-diabetic participants.

Methods. This study included 5,688 participants, aged 45-84 years, without clinical cardiovascular disease, and not taking lipid lowering medications at baseline, from the Multi-Ethnic Study of Atherosclerosis. Proportional hazards models were used to evaluate associations of triglyceride, total cholesterol/high density lipoprotein-cholesterol (TC/HDL-C) ratio, HDL-C and non HDL-C with incident HF, testing for effect modification by diabetic status.

Results. Over a median follow up of 7.6 years, there were 139 cases of incident HF. The associations of triglyceride with incident HF varied by diabetes status (P_interaction = 0.04). In diabetic participants, triglyceride, HDL-C and TC/HDL-C ratio were associated with incident HF after adjusting for confounders and comorbidities (Table). Lipid measures were not associated with incident HF in non-diabetic individuals.

Conclusions. Triglyceride, HDL-C and TC/HDL-C ratio are independently associated with incident HF in diabetic, but not in non-diabetic individuals.