Abstract 11009: Successful Implantation of a Completely Autologous Aortic Valve With a Stent (Biovalve Stent) by Transcatheter Aortic Valve Implantation (TAVI)
Purpose: An autologous aortic valve with a metallic stent (Biovalve Stent) was developed, using simple, safe and economical in-body tissue engineering. In this study, the potential of the Biovalve Stent for transcatheter aortic valve implantation (TAVI) was investigated in a goat model.
Methods: Biovalve Stents were prepared by 2-month embedding of the molds, assembled using plastic rods and a metallic stent, in the subcutaneous spaces of goats. After extracting the molds and removing the plastic rods only, Biovalve Stents with tri-leaflets similar to those of the native aortic valves were constituted from completely autologous connective tissues. Four out of eight Biovalve Stents were implanted in the apico-aortic bypass of goats for 1 month to evaluate the valvular function under the systemic circulation and other four Biovalve Stents were implanted in the in situ aorta with TAVI apical approach.
Results: In the apico-aortic bypass cases, postoperative echocardiography and angiography showed smooth movement of the leaflets with a little regurgitation under the systemic circulation. Three out of 4 cases were continued for 1 moth. In the TAVI cases, the Biovalve Stents were successfully implanted into the aorta. Histological examination 2 months after TAVI, showed the endothelial cells covering the laminar surface of the valve leaflets and cell populations inside the valves.
Conclusion: The Biovalve Stent satisfied the higher requirements of systemic circulation in goats for 2 months with the potential for TAVI.
- © 2012 by American Heart Association, Inc.