Abstract 10901: Decreased Levels of Endogenous Plasma Active Glucagon Like Peptide-1 were Correlated with Endothelial Dysfunction in Patients with Coronary Risk Factors
Background: Endothelial dysfunction has been involved in atherogenesis. Glucagon like peptide-1 (GLP-1) analogues have shown beneficial effects on cardiovascular functions in addition to its glycemic actions. However relationship between endogenous plasma active GLP-1 levels and endothelial dysfunction has not been fully understood.
Methods: We enrolled 140 stable patients with coronary risk factors, including coronary artery disease (CAD). We assessed endothelial function by measuring reactive hyperemia peripheral arterial tonometry index (RHI) and fasting plasma active GLP-1 levels by ELISA at stable condition.
Results: Total patients (age 65.5±10.0, man 65.0%, hypertension 74.3%, diabetes mellitus 32.1%, dyslipidemia 76.4%, CAD 58.6%) were divided into the normal endothelial function (N-EC) group (RHI 0.782±0.163, n=75) and the endothelial dysfunction (D-EC) group (RHI 0.427±0.132, n=65) by cutoff value of RHI; 0.56. The patients with D-EC were significantly older than patients with N-EC. Levels of high density lipoprotein cholesterol in patients with D-EC were significantly lower (49.2±13.5 vs. 55.7±11.7mg/dl, P<0.01), and levels of high sensitive C-reactive protein in patients with D-EC were significantly higher than those with N-EC (0.80[0.30-1.63] vs. 0.40[0.20-0.80]mg/l, P<0.05). There were significantly more subjects with undetectable active GLP-1 (<2.0pM) in the D-EC patients than in the N-EC patients (n=12 vs. n=5, P<0.05). Furthermore, the fasting plasma levels of active GLP-1 in patients with D-EC were significantly lower than in those with N-EC, excluding patients with undetectable active GLP-1 (3.20 [2.68-3.85] vs. 3.75 [2.90-4.80]pM, P<0.05). Multivariate logistic regression analysis revealed that the lower active GLP-1 (<3.3pM: median value) independently correlated with the presence of endothelial dysfunction after adjustment with significant factors by univariate analysis (odds ratio 2.12, 95% confidence interval 1.03-4.38, P<0.05).
Conclusion: The fasting plasma levels of active GLP-1 in patients with D-EC were significantly lower than those in N-EC patients, and the lower active GLP-1 independently correlated with the presence of endothelial dysfunction in patients with coronary risk factors.
- © 2012 by American Heart Association, Inc.