Abstract 10747: Age is Related to Interstitial Myocardial Fibrosis in Asymptomatic Adults: Magnetic Resonance T1 Mapping in the Multi-ethnic Study of Atherosclerosis (MESA)
Introduction: Animal and human studies have demonstrated increased collagen deposition in senescent hearts. Cardiac magnetic resonance (CMR) indices of tissue composition using T1 mapping are sensitive to the presence of myocardial fibrosis. The purpose of this study was to determine the relationship of CMR measures of tissue composition to age in MESA.
Methods: 585 women and 534 men (age 52-93) of the MESA cohort were evaluated using 1.5T CMR scanners. All participants did not have findings of delayed enhancement. Single slice T1mapping was performed at the mid-ventricular level before and at 12 and 25 minutes delay after administration of gadolinium (Magnevist; 0.15mmol/kg) using a Modified Look Locker Inversion Recovery sequence. Partition coefficient was determined by the slope of linear relationship of (1/T1myo vs. 1/T1blood) at various time points. Extracellular volume fraction (ECV) was derived accounting for the hematocrit. Multivariable regression analysis was performed, adjusting for traditional risk factors and left-ventricular structure.
Results: Women had significantly higher partition coefficient, pre-contrast T1, and ECV, but lower post-contrast T1 than men (Table 1). Linear regression analyses (Table 2) demonstrate that greater partition coefficient, pre-contrast T1, and ECV were associated with older age. Greater post-contrast T1 and T1 change (ΔT1/Δt) were also associated with older age. These relationships were stronger in men than in women.
Conclusion: CMR parameters that are associated with fibrosis were related to older age in the MESA study. These fibrosis indices suggest greater age-related change in men than women.
- © 2012 by American Heart Association, Inc.