Abstract 10615: Proteinuria Predicts All-cause and Cardiovascular Mortality in Non-hypertensive, Non-diabetic Japanese with Preserved Renal Function

Abstract

Background: Although proteinuria has been associated with all-cause and cardiovascular mortality independent of hypertension or diabetes mellitus, the impact of proteinuria on all-cause and cardiovascular mortality has not been estimated separately in non-hypertensive, non-diabetic subjects with preserved renal function.

Methods: We studied subjects who had the annual health examination offered to adult citizens of Moriguchi city, Osaka, Japan in 1997. Subjects who had history of cardiovascular disease, hypertension, diabetes, or estimated glomerular filtration rate <60 mL/min/1.73m² were excluded. Association of all-cause and cardiovascular mortality with proteinuria was assessed using proportional hazards regression analyses. Proteinuria was defined as urine protein + or higher measured by a urine dipstick test on a spot urine collection.

Results: There were 9,419 subjects with a mean age of 50±13 years and 22.8 % of men. Proteinuria was observed in 2.2%. During a mean follow-up of 11.0±3.1 years (median 12.2 years), there were 405 deaths including 59 cardiovascular deaths. Proteinuria was associated with all-cause (HR=2.27, 95%CI=1.51 to 3.41, p<0.0001) and cardiovascular mortality (HR=3.24, 95%CI=1.37 to 7.64, p=0.0074) after adjustment for age, sex, hypercholesterolemia, smoking, and alcohol drinking status.

Conclusions: Proteinuria was substantially associated with all-cause and cardiovascular mortality even in subjects without hypertension, diabetes, or renal dysfunction.