Abstract P375: Vitamin D Deficiency is Associated with Hypertriglyceridemic Waist Phenotype
Introduction: Hypertriglyceridemic waist phenotype (TGW) is a clinical indicator of visceral obesity. Studies have shown that TGW predicts adverse cardiovascular outcomes. Vitamin D (Vit D) deficiency is a novel and reversible nutritional risk factor for metabolic syndrome and cardiovascular disease. This is the first study of its kind, looking at whether Vit D deficiency predicted TGW.
Methods: We did a post-hoc analysis of 2301 subjects from the National Health and Nutrition Examination Survey III (1988-1994). Patients without Vit D, waist circumference (WC) and serum triglycerides (TG) measurements were excluded. TGW was defined as WC ≤85 cm and 90 cm and TG ≤1.5 mmol/l (132 mg/dl) and 2 mmol/l (177 mg/dl) in females and males respectively. Subjects were divided into equal quartiles based on serum vit D levels. Stata 11 was used to perform chi-square test for categorical variables, t-test for continuous variables and univariate and step-wise multivariate logistic and linear regression.
Results: Out of 2301 subjects, 35% (798) met the definition of TGW. Patients with TGW were older (61±12 vs. 60±13 yrs, p 0.01), males (43% vs. 56%, p<0.001), dyslipidemic (58% vs. 42%, p<0.001), diabetic (17% vs. 10%, p<0.001), hypertensive (63% vs. 51%, p<0.001) and had lower serum vit D levels (22.1±8.7 vs. 23.2±9.2, p 0.008). Vit D level was negatively associated with TGW (coef -0.024, CI -0.036 to -0.013, p<0.001). Patients having serum vit D level >28 ng/ml (highest quartile) were significantly less likely to have TGW than patients having vit D level <17 ng/ml (lowest quartile) after adjusting for age, sex, race, GFR, calcium, parathyroid hormone, hypertension, hypertension medications, hyperlipidemia, hyperlipidemia medications, diabetes, end stage renal disease and hemodialysis (OR 0.56, CI 0.42-0.75, p<0.001).
Conclusion: Vit D deficiency is an independent predictor of TGW. Randomized controlled trials are needed to determine whether supplementation will improve cardiovascular outcomes.
|Vitamin D Quartile Q1 (<17 ng/ml) reference category||Odds ratio||95% CI||P value|
|Q2 (17-22)||0.84||0.65 to 1.09||0.19|
|Q3 (23-28)||0.63||0.48 to 0.83||0.001|
|Q4 (>28)||0.56||0.42 to 0.75||<0.001|
- © 2012 by American Heart Association, Inc.