Abstract P366: A High-carbohydrate Diet Increases Serum HDL-C and Apolipoprotein A-I and Decreases Weight and BMI in the Male A Carriers of the APOA1 -75G/A Polymorphism
Both apolipoprotein gene polymorphism and high-carbohydrate diet have been found to be associated with serum lipid levels. However, the effects of their interaction on serum lipid profiles have not been well elucidated yet. We assessed the hypothesis that the subjects with different genotypes of the -75G/A polymorphism in the promoter region of the apolipoprotein A-I gene (APOA1) have different serum lipid responses upon a high-carbohydrate diet. Fifty-six healthy university students (27 males and 29 females, 22.89±1.80 years) were given a washout diet of 54% carbohydrates for seven days, followed by a high-carbohydrate diet of 70% carbohydrates for six days without total energy restriction. Anthropometric indexes and serum lipids at baseline, after the washout diet, and after the high-carbohydrate diet, as well as the APOA1 -75G/A polymorphism were analyzed. The male A carriers of the APOA1 -75G/A polymorphism consistently had higher levels of apolipoprotein A-I (p=0.008 at baseline, p=0.031 after the washout diet, and p=0.009 after the high-carbohydrate diet diet), but higher levels of high-density lipoprotein cholesterol (HDL-C) only at baseline (p=0.048) and after the high-carbohydrate diet (p=0.042) than the males with the GG genotype, and experienced increases in HDL-C (p=0.023) and apolipoprotein A-I (p=0.012) and decreases in body weight (p=0.017) and body mass index (BMI) (p=0.018) after the high-carbohydrate diet when compared to those after the washout diet. In conclusion, the high-carbohydrate diet can increase the serum HDL-C and apolipoprotein A-I concentrations in the males carrying the A allele of the APOA1 -75G/A polymorphism. The effects are associated with the decreases of body weight and BMI. These results may provide experimental evidences for the personalized dietary interference in the country with the largest population in the world.
- © 2012 by American Heart Association, Inc.