Abstract P302: Baseline Measures of Adiponectin, Systolic Blood Pressure and Drinking Alcohol are Associated with More Aortic Stiffness Progression among Men: The ERA JUMP Study
Objective: Aortic stiffness, a significant marker of vascular aging, is independently associated with CVD and all-cause mortality. Limited data are available about risk factors for the progression of aortic stiffness in healthy population. We examined several baseline risk factors as possible independent predictors of aortic stiffness progression among US men.
Design: Participants were a population-based sample of black and white men aged 40–49 from the Pittsburgh site of the ERA JUMP Study, who were free of CVD at baseline. Aortic stiffness was measured as carotid-femoral pulse wave velocity (cfPWV) using an automated waveform analyzer at baseline and after 4.6±0.21(mean±SD) years of follow-up. Progression of cfPWV was evaluated as: 1) occurrence of progression (defined as ≥ 75th percentile of the change in cfPWV since baseline (≥ 118.5 cm/s increase); and 2) severity of progression as the difference between the natural-log cfPWV at follow-up and the natural-log cfPWV at baseline. Systolic BP (SBP), BMI, visceral adiposity, lipids, glucose, insulin, adiponectin, PAI-1, fibrinogen, CRP, alcohol drinking, and smoking status at baseline were evaluated as possible risk factors for occurrence and severity of cfPWV progression. Stepwise logistic and linear regression models were utilized as appropriate. In univariate analysis, risk factors found to be associated with cfPWV progression at a P value ≤ 0.25 were eligible for stepwise regression analysis. Variables were dropped from models at a P value > 0.1. Age at baseline, follow-up time, race, heart rate, and medication use were forced in all models.
Results: A total of 240 men (White:82.5%, Black:17.5%) who were 45.0±2.9 years old at baseline, were included in this analysis. During follow-up, cfPWV progressed in 125 participants (52.0%) with a median increase of 113.5 cm/s (Q1=46.0, Q3=204.5). Final models revealed that independent predictors of the occurrence of cfPWV progression were lower levels of adiponectin (OR: 0.46, 95%CI: 0.23, 0.95, P=0.04), higher levels of SBP (OR: 1.03, 95%CI: 1.002, 1.06, P=0.04) and drinking alcohol ≥ 2 times/week (OR: 1.92, 95%CI: 1.01, 3.64, P=0.046) at baseline. Similarly, adiponectin (β=−0.097(SE=0.04), P=0.02) and drinking alcohol ≥ 2times/week (β=0.084(SE=0.04), P=0.02) were also independent predictors of severity of cfPWV progression. No significant interactions were found between these predictors and race.
Conclusions: Independent of age at baseline, follow-up time, race, heart rate and medication use, lower levels of adiponectin, higher levels of SBP and drinking alcohol ≥2 times/week at baseline are associated with greater progression in aortic stiffness among relatively young middle-aged US men.
- © 2012 by American Heart Association, Inc.