Abstract P284: Antibody Levels to Persistent Pathogens and Incident Stroke in Mexican Americans
Infectious pathogens such as Cytomegalovirus, Helicobacter Pylori, Toxoplasma gondii, Varicella Zoster and Herpes Simplex Virus Type 1 confer lifelong infections that are prone to reactivation. These pathogens may have an effect on ischemic stroke risk through an inflammatory pathway. Disparate rates of infectious disease and stroke risk have been documented for Mexican Americans (MAs) compared with Non-Hispanic Whites, thus exposure to persistent pathogens may help to explain the excess stroke burden in this population. We examined the hypothesis that high antibody response to 5 pathogens increases stroke risk in an elderly cohort of MAs. The study population included individuals followed from 1998-2008 as part of the Sacramento Area Latino Study on Aging (n=1789). Those with prevalent stroke at baseline were excluded (n=168). Seven annual in-person interviews and six semi-annual telephone interviews were conducted to ascertain clinical data and sociodemographics, with serum tested for IgG antibody levels. Antibody levels for each pathogen were modeled based on quartiles of the distributions. The outcome was self-reported incident stroke during follow-up. Associations between antibody levels for each pathogen and stroke risk were investigated using discrete-time logistic regression. We used baseline data and updated longitudinally collected covariate information if available. Mean age of our sample (n=1621) was 73.2 (SD=6.9), with 41% male. During the study, 164 incident strokes occurred. In demographic-adjusted models, no significant association was found between antibody levels for any of the pathogens and incident stroke. Similar results were found after additional adjustment for known stroke risk factors (Table). In conclusion, antibody levels to five persistent pathogens were not significantly associated with increased stroke risk in this elderly cohort of MAs. Given our results, future research should assess the effect of pathogen burden (or, the effect of >1 pathogen), on stroke risk in MAs.
|Cytomegalovirus||Herpes Simplex Virus Type1||Toxoplasma Gondii||Varicella Zoster Virus||Helicobacter Pylori|
|Odds Ratio||95% CI||P value||Odds Ratio||95% CI||P value||Odds Ratio||95% CI||P value||Odds Ratio||95% CI||P value||Odds Ratio||95% CI||P value|
|Quartile 2||0.79||0.48, 1.31||1.11||0.69, 1.80||0.94||0.59, 1.50||1.21||0.77, 1.92||0.94||0.56, 1.57|
|Quartile 3||0.99||0.62, 1.58||1.06||0.66, 1.69||0.94||0.58, 1.54||0.89||0.54, 1.46||1.53||0.97, 2.43|
|Quartile 4||0.79||0.48, 1.29||0.88||0.54, 1.43||0.91||0.56, 1.48||0.78||0.48, 1.28||1.51||0.94, 2.42|
95% CI= 95% Confidence Interval; Adjusted for age, sex, diabetes, atrial fibrillation, smoking, coronary heart disease, hypertension, and hyperlipidemia
- © 2012 by American Heart Association, Inc.