Abstract P176: Associations of Cardiovascular Disease Risk Factors with Aorto-Iliac Bifurcation Location
Objectives: We investigated associations of cardiovascular disease (CVD) risk factors and calcified atherosclerosis with the aortic bifurcation location.
Background: In older persons, the aorto-iliac bifurcation is found in a more caudal position along the lumbar spine. Little is known about what other factors may play a role in the location of the bifurcation.
Methods and Results: We evaluated community living individuals, free of clinical CVD, who had completed abdominal, computed tomography (CT) scans. The aorto-iliac bifurcation distance (AIBD), bifurcation to L5-S1 disc space, was determined from CT scans. The 1,711 participants (51% male) in this study had a mean age of 62 ± 10 years, and a mean AIBD of 26 ± 15mm. Age was a strong correlate of AIBD, such that on average, individuals > 80 years had bifurcations positioned 16mm lower than individuals < 50 years. In multivariable linear regression, standardized for lumbar spine height, older age, smoking, hypertension, and larger aortic diameter (ADD) were each independently associated with a smaller AIBD (more caudal location of the bifurcation). In contrast, diabetes and elevated triglycerides were independently associated with a larger AIBD (more cephalad location).
Conclusions: A more caudal position of the aorto-iliac bifurcation is associated with some, but not all, CVD risk factors. Future studies should access the position of the bifurcation as a useful surrogate for vascular aging, or a prognosticator for CVD.
- © 2012 by American Heart Association, Inc.