Abstract P172: Birth Weight, Maternal Pre-pregnancy Body Mass Index and Adulthood Vitamin D Levels: The Jerusalem Perinatal Study
Background: The intrauterine experience and pre-pregnancy maternal characteristics have demonstrated importance in the development of life course risk for chronic diseases. Vitamin D has been associated with several chronic diseases including cardiometabolic diseases. Whether offspring birth weight and maternal pre-pregnancy body mass index (BMI) are associated with adulthood vitamin D levels is unknown. Further, the role of adulthood BMI in these relationships is not clear.
Methods: We examined associations of offspring birth weight and maternal pre-pregnancy BMI with offspring adulthood vitamin D levels among a subset of the Jerusalem Perinatal Study (JPS) population, a birth cohort of Jerusalem residents born between 1974 and 1976. Offspring aged 30-35 years, sampled based on maternal pre-pregnancy body mass index (BMI) and offspring birth weight, and their mothers were recruited as part of the JPS-1 study. Data were collected using interviews and field physical examinations. Fasting blood specimens were obtained for vitamin D measurements. We used liquid chromatography-tandem mass spectroscopy to measure total vitamin D (25-[OH] D). Sample-weighted multiple regression models, adjusted for potential confounders, were used to examine associations, and determine coefficients and 95% confidence intervals.
Results: Mean total vitamin D levels was 23.48ng/ml among study participants. Birth weight was not related to vitamin D levels in adulthood. Pre-pregnancy BMI was inversely associated with offspring adulthood vitamin D levels, both before (β=-0.24, p-value=0.005) and after adjustment for birth weight (β=-0.24, p-value=0.015). However, the association was attenuated by including current offspring BMI in the models (β=-0.17, p-value=0.061) or both current BMI and birth weight (β=-0.16, p-value=0.120). In addition, the association between maternal pre-pregnancy BMI with current offspring BMI was not altered by adulthood vitamin D level.
Conclusion: Maternal pre-pregnancy is potentially associated with adulthood vitamin D levels. This association may be mediated at least in part by offspring current BMI. Future studies are warranted to investigate whether the observed associations are due to genetic factors or other characteristics of the intrauterine environment.
- © 2012 by American Heart Association, Inc.