Abstract P158: Excess CVD Risk Factors, CAC and Carotid IMT in US South Asians: Preliminary Results from the MASALA study
Background: South Asians (SA) have a disproportionate risk of heart disease and diabetes and are at greater risk for death from heart disease compared to other racial/ethnic groups. There are almost 3 million SA in the United States; SA are currently the second fastest growing U.S. ethnic group after Latinos.
Objectives: To assess the prevalence of cardiovascular (CVD) risk factors and subclinical atherosclerosis in SA using similar methods and measures from the Multi-Ethnic Study of Atherosclerosis (MESA).
Methods: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) study is a community-based cohort enrolling 900 SA between 40-79 years without known CVD at two clinical centers (University of California, San Francisco and Northwestern University, Chicago). At baseline, we are collecting demographic, cultural and lifestyle information, fasting blood tests, 2-hour glucose tolerance test, physical examination, carotid ultrasound for intima media thickness (IMT) and CT for coronary artery calcium (CAC).
Results: To date, we have enrolled 368 participants in MASALA with a mean age of 56±9 years, of whom 98% are immigrants who have lived in the U.S. an average of 27±11 years. A majority are immigrants from India (85%), 6% from Pakistan, 1% each from Bangladesh, Sri Lanka and Nepal, and 6% from other diaspora countries. The table shows demographic, behavioral, and clinical characteristics of the cohort. The cohort has higher socioeconomic status, lower smoking and alcohol use, very low exercise, modest BMI, and higher prevalence of hypertension, diabetes, and subclinical atherosclerosis than reported in MESA ethnic groups.
Conclusion: Despite having high socioeconomic attainment and modest BMI, SA have low physical activity levels and high prevalence of CVD risk factors and atherosclerosis. This population-based study of U.S. South Asians will provide further insights into the clinical, behavioral, and socio-cultural factors contributing to heart disease.
|Overall n=368||Men n=271||Women n=97|
|Education ≥Bachelor's degree, %||86||87||83|
|Family income ≥$100,000, %||60||62||55|
|Current smoking, %||5||6||1|
|Alcohol intake, >1 drink/week||39||45||22|
|Exercise, median MET-min/week||960||982||885|
|Waist circumference, cm||95±10||97±10||91±11|
|HDL, mg/dl (median)||47||44||57|
|Triglycerides, mg/dl (median)||122||127||112|
|Common carotid IMT, mm||0.91±0.22||0.92±0.22||0.89±0.24|
|Internal carotid IMT, mm||1.24±0.44||1.24±0.45||1.22±0.42|
|CAC score, zero 1-100 >100||50 31 19||44 35 21||69 20 11|
- © 2012 by American Heart Association, Inc.