Abstract P114: Interaction of Dietary n-3 Fatty Acids on Cardiac Risk by J-point Elevation in Japanese Men: NIPPON DATA80
Background: Early repolarization, characterized by an elevation of QRS-ST junction (J-point) on a 12-lead electrocardiography, has recently been considered an independent predictor of cardiac or sudden death. Meanwhile, protective effects of n-3 fatty acids (FAs) on cardiovascular diseases have been demonstrated in epidemiologic studies and clinical trials. Therefore, we assessed the hypothesis that an increased dietary intake of n-3 FAs may reduce poor prognosis of J-point elevation (JpE).
Methods: A total of 4443 community-dwelling men (mean age of 49.5 years) without previous cardiovascular diseases from randomly selected areas across Japan were included for the analysis. The primary endpoint was cardiac death during a mean follow-up of 20.4±6.1 years. JpE was defined as an elevation of J-point at least one lead: ≥0.2mV in V1-4 leads or ≥0.1mV in other leads. Dietary intakes of n-3 FAs were calculated by a combined method using household-based food-weighing records and an approximation of the proportions of each dish or food shared in the household. The hazard ratios (HRs) (95% confidence interval [95%CI]) of JpE for cardiac death were estimated by Cox proportional hazard models adjusted for age, sex, body mass index, systolic blood pressure, total cholesterol, diabetes mellitus, smoking status, drinking habits, medication status, cohort, heart rate, dietary sodium, dietary fiber, dietary saturated fatty acids, high R wave on electrocardiography (based on Minnesota Codes 3.1 and 3.3), and suspected coronary heart disease on electrocardiography (based on Minnesota Codes 1.1 to 1.3, 5.1 to 5.2, 4.1 to 4.3, 7.1, and 7.4).
Results: JpE were present in 153 of 2176 (7.0%) and 187 of 2267 (8.2%) individuals in low (<the median n-3 FAs level of 1.06%kcal) and high (≥1.06%kcal) n-3 FAs groups, respectively. During follow-up period, the number of deaths from cardiac causes in low and high n-3 FAs groups were 128 (5.9%) and 85 (3.7%), respectively. In the low n-3 FAs group, individuals with JpE had a significantly higher HR of cardiac death than those without JpE (2.77; 95%CI, 1.60-4.82; P=0.001). In contrast, in the high n-3 FAs group, a HR was not significantly increased (0.85; 95%CI, 0.37-1.97; P=0.711) (P for n-3 FAs-JpE interaction = 0.032).
Conclusions: An increased risk of cardiac death related to JpE was attenuated in individuals with higher dietary intake of n-3 FAs, suggesting that a higher n-3 FAs intake may prevent long-term cardiac risk associated with JpE
- © 2012 by American Heart Association, Inc.