Abstract P102: Circulating Adipocytokines and Risk of Chronic Kidney Disease
Recent studies have found a link between obesity and chronic kidney disease (CKD). However, the mechanism for this association is not well understood. Obesity-related CKD may be partially mediated by adipocytokines, including leptin, resistin, and adiponectin. In this study we investigated the association of plasma leptin, resistin and adiponectin with risk of CKD in 201 cases with CKD and 201 controls without. CKD was defined as estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 or presence of albuminuria. Median levels of adipocytokines and odds ratios of CKD were estimated and adjusted for age, gender, race, smoking, drinking, education, physical activity, systolic blood pressure, glucose, low-density lipoprotein cholesterol, and body mass index. Compared to controls, adjusted median plasma leptin (38,385 vs. 17,303 ng/mL, p<0.0001) and resistin (15.0 vs. 8.0 ng/mL, p<0.0001) were significantly higher in CKD cases. The median ratio of high molecular weight adiponectin to total adiponectin was lower in cases than in controls (0.38 vs. 0.43, p=0.0001). The odds ratios (OR) for CKD comparing the highest third to the lowest two thirds of leptin was 4.7 (95% CI, 2.2, 9.8) and of resistin was 17.0 (95% CI, 8.4, 34.2). A non-significant weak inverse effect was seen when comparing the highest third to the lowest two thirds of the adiponectin ratio with an OR of 0.8 (95% CI, 0.4, 1.3). The results did not change substantially after further adjustment for history of cardiovascular disease. Our study found that increased leptin and resistin are associated with an increased risk of CKD. In conclusion, these findings suggest that adipocytokines may play a role in the etiology of CKD. Longitudinal studies are warranted to further evaluate the causal relationship of these adipocytokines with development of CKD.
- © 2012 by American Heart Association, Inc.