Abstract P057: Adiposity Associated Inflammation and Hypertension
Background: The aim of this study was to test whether selected markers of adiposity associated inflammation (adipokines) are associated with hypertension (HTN) and isolated systolic hypertension (ISH).
Methods: Subjects were 1970 individuals who were enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA). Subjects provided a wide range of health history information and had several physical measurements performed. Blood pressure was measured three times using a standard protocol, with the last two measurements being averaged. HTN was defined as a systolic blood pressure (SBP) > 140 mmHg, diastolic blood pressure (DBP) > 90 or taking a blood pressure medication while ISH was SBP > 140 or taking a blood pressure medication and a DBP <= 90. Fasting venous blood collected at this visit was analyzed for the following adipokines: leptin, adiponectin, tumor necrosis factor - alpha and resistin.
Results: The mean age was 64.7 years and 50% were female. The mean SBP, DBP, mean arterial pressure (MAP) and pulse pressure (PP) was 124, 70, 88 and 54 mmHg, respectively. Forty-four percent had HTN. The Table shows the results of multivariable logistic regression for the adipokines and both HTN and ISH. As shown, leptin was consistently associated with a significantly higher odds for the presence of either HTN and ISH. This applies to whether leptin was utilized as a continuous or categorical variable (in quartiles). Adding body mass index to model #3 modestly attenuated the associations, but remained statistically significant (p ≤ 0.01 for all). Associations for the other adipokines were inconsistent and not significant after full adjustment.
Conclusion: Higher leptin, but not the other adipokines studied, is significantly associated with diagnoses of both hypertension and isolated systolic hypertension independent of relevant covariates including body mass index. This suggests that leptin may have an influence on blood pressure beyond the effects of adiposity.
- © 2012 by American Heart Association, Inc.