Abstract P045: Residential Traffic Exposure and Intima Media Thickness in Augsburg, Germany
Background. It has been suggested that long-term exposure to air pollution may lead to an increased risk of cardiovascular disease.
Hypotheses. In this study, we hypothesized that long-term residential traffic exposure enlarges of intima-media thickness (IMT).
Methods. We used data on 2712 individuals aged 31 to 82 years who participated in the cross-sectional KORA F4 (2006–2008) survey conducted in the region of Augsburg, Germany. The residential traffic exposure was assessed by specifying daily traffic intensity of and distance to nearest street, and of daily traffic load (sum of product of traffic intensity and length of all street segments) and total road length within a buffer of 50 and rings of 50 to 100 and 100 to 300 meters around the residences. IMT was measured as mean of first cm of left and right common carotid artery segments from all angles (mm). We used linear regression adjusting for sex, age, adipositas, education, occupation, smoking status, systolic and diastolic blood pressure, HDL- and LDL-cholesterol and statin intake.
Results. Road length within a radius of 50 meters of a person’s residence was associated with an increased IMT 1.2% (95% CI, 0.2% to 2.3%) per increase in 140 road length (m). Other measures of traffic exposures showed no or weaker effects; for example the traffic load within a radius of 50 meters of a person’s residence was associated with an increased IMT 0.3% (95% CI, -0.4% to 1.0%) per increase in 600 vehicles per kilometer. No difference was observed between men and women.
Conclusions. Long-term residential exposure by road traffic may contribute to the development of atherosclerosis. Additional estimates for traffic related pollution may help interpreting the results of the KORA study.
- © 2012 by American Heart Association, Inc.