Abstract P018: Circulating Levels of Endostatin are Related to Future Cardiovascular Mortality in Elderly subjects
Background: Endostatin, a biological active fragment of the extracellular matrix protein collagen XVIII, is known to be involved in angiogenesis. We evaluated if circulating lvels of this compound was related to future mortality in two different cohorts of elderly subjects.
Methods: In the PIVUS cohort of 931 subjects all aged 70 years at baseline, 90 individuals died during a median follow-up of 7.9 years. In the ULSAM cohort of 748 men aged 77 years at baseline, 261 individuals died during a median follow-up of 8.1 years.
Results: Circulating levels of endostatin were related to future all-cause mortality in both samples following adjustment for age, gender, education, exercise habits, smoking BMI, blood pressure, lipids, diabetes and prior cardiovascular disease (HR 1.54 for a 1 SD change, 95%CI 1.26-1.90, p<0.0001 in PIVUS and HR 1.35, 95%CI 1.18-1.54 in ULSAM, both p<0.0001). In ULSAM, in which the cause of death was known, the HR was higher for cardiovascular mortality (HR 1.47, 95%CI 1.22- 1.780, p<0.0001).
Conclusion: Endostatin was related to future mortality in two elderly Swedish sohorts independently of life-style factors and cardiovascular risk factors. The fact that the HR for cardiovascular mortality was higher than for all-cause mortality indicates a role of endostatin in the pathogenesis of cardiovascular diseases.
- © 2012 by American Heart Association, Inc.