Abstract MP093: Clinical Features, Treatment Practices, and Short-term Outcomes of Patients < 55 Years of Age Hospitalized with an Acute Coronary Syndrome: The Global Registry of Acute Coronary Events
Limited data are available describing the magnitude, clinical features, treatment practices, and short-term outcomes of comparatively young adults hospitalized with acute coronary syndromes (ACS). The objectives of this large multinational observational study, using data from the GRACE Registry, were to describe nearly decade long trends in these endpoints among adults < 55 years old who were hospitalized with an ACS between 1999 and 2007. The overall proportion of young adult patients in our study population was 23% (n=15,052 of 65,119) and this proportion remained relatively constant over the study years. Baseline demographic and clinical characteristics of our study sample did not change significantly, whereas, the length of hospital stay declined by more than 1 day, on average, during the years under study. The overall in-hospital and 30-day multivariable adjusted case-fatality rates (CFRs) declined by approximately one-third (table) between 1999 and 2007 (crude 30-day CFR= 2.4% in 1999 and 1.7% in 2007). The use of evidence-based cardiac therapies demonstrated to improve outcomes of patients with an ACS increased significantly over time. In conclusion, improving trends in short-term outcomes of comparatively young patients hospitalized with an ACS during the nearly decade long period under study likely reflect enhanced primary and secondary prevention and treatment efforts. Odds of Dying in Younger Patients Hospitalized with an Acute Coronary Syndrome
|Study Period||Crude Odds Ratios of In-Hospital Death||Multivariable Adjusted Odds Ratios of In-Hospital Death*||Crude Odds Ratios of 30-day Death||Multivariable Adjusted Odds Ratios of 30-day Death*|
|2002-2004||0.89 (0.82-0.97)||0.83 (0.76-0.91)||0.93 (0.86-1.0)||0.83 (0.76-0.90)|
|2005-2007||0.74 (0.67-0.81)||0.66 (0.60-0.74)||0.74 (0.68-0.81)||0.62 (0.57-0.69)|
↵* Adjusted for age, sex, length of hospital stay, and medical history ºreferent period
- © 2012 by American Heart Association, Inc.