Abstract MP090: “Life’s Simple 7” and Risk of Incident CHD in the REasons for Geographic And Racial Differences (REGARDS) Study
The American Heart Association’s “Life’s Simple 7” (LS7) is a tool intended to encourage improvements in cardiovascular health. It is not clear whether LS7 scores are associated with similar risks for fatal and nonfatal acute coronary heart disease (CHD) events across race-sex groups in the 21st century. REGARDS is following 30,239 community-dwellers age >45 years recruited between 2003-7 from the contiguous US states. Recruitment was designed to balance race and sex; the final sample was 55% female and 41% black. Participants were telephoned every 6 months for cardiovascular disease endpoints, with retrieval of medical records, death certificates, interviews with next-of-kin or proxies, and expert adjudication of endpoints following national consensus recommendations. Acute CHD was defined as definite or probable myocardial infarction (MI) not resulting in death within 28 days (nonfatal acute CHD) or fatal acute CHD. Among participants free of CHD at baseline, we used Cox models to examine hazard ratios for incident overall acute CHD, and, separately, fatal and nonfatal acute CHD for white and black men and women through 2008, examining associations with LS7 score (blood pressure, cholesterol, glucose, body mass index, smoking, physical activity, and diet), each scored as poor (1 point), intermediate (2 points) or ideal (3 points). The score ranged from 7-21 with 21 being the best cardiovascular health. The study sample numbered 24,431 with mean age 64.1 (SD+9.3) years. Mean follow-up over 3.4 (maximum 5.9) years resulted in 515 incident acute CHD events (355 nonfatal, 160 fatal). Race-sex specific hazard ratios for incident acute CHD and incident nonfatal acute CHD per point higher LS7 score are shown in the table. The AHA’s goal of improving cardiovascular health by 20% by 2020 as assessed by LS7 could have major impact on improving CHD outcomes among black and white Americans.
- © 2012 by American Heart Association, Inc.