Abstract MP084: Childhood and Adult Environmental Tobacco Smoke and Risk of Incident Type 2 Diabetes Among Never-smoking French Women
Background There is consistent evidence of a direct relation between active smoking and type 2 diabetes. However, prior studies on passive smoking (or secondhand smoke) and type 2 diabetes have often been limited by insufficiently detailed information on both childhood and adult environmental tobacco smoke exposure.
Methods and Results We evaluated childhood and adult environmental tobacco exposure (ETS) in relation to incident type 2 diabetes in a prospective cohort study among 37,343 never-smoker women from the E3N-EPIC cohort, who were free of diabetes, cancer or cardiovascular disease at baseline in 1992. Self-reported childhood ETS was defined as having at least one parent who smoked (59 % of women). Adult ETS exposure was defined as the sum of self-reported hours of exposure to tobacco from a smoking spouse (or domestic close contact) and exposure to ETS outside the home, recorded at baseline. Between 1992 and 2007, 795 cases of incident diabetes were identified and validated using a drug reimbursement dataset and a specifically designed supplementary questionnaire. Adjusting for family history of diabetes, education and body silhouette at age 18 women with at least one smoking parent had an 18 % higher rate of diabetes compared to women with nonsmoking parents [HR=1.18 (95%CI 1.02-1.86)]. After additional adjustment for physical activity, BMI, parental smoking, treated hypertension and hypercholesterolemia, menopausal status and menopausal hormone use the multivariate HRs (95%CI) for adult ETS exposure relative to no exposure were 1.08 (0.92, 1.27) for < 1 hours/day, 1.06 (0.77, 1.46) for 1 to 1.9 hours/day, 1.34 (1.00, 1.82) for 2 to 3.9 hours/day and 1.44 (1.11, 1.86) for ≥ 4 hours/ day with p for trend 0.003.
Conclusion Childhood and adult ETS exposure may be associated to a higher rate of type 2 diabetes. These results further emphasize the health risks of past and current tobacco smoke exposure.
- © 2012 by American Heart Association, Inc.