Abstract MP058: Longitudinal Determinants of LV Mass and Geometry: The CARDIA Study
There is little long term data on LV mass and geometry. The Coronary Artery Disease in Young Adults Study (CARDIA), a longitudinal study of the evolution of cardiovascular disease risk factors in young adults, performed echocardiograms in years 5 and 25. The purpose of this study is to assess change in prevalence of LV hypertrophy and LV geometry categories (LV mass > 51g/m2.7= LV hypertrophy; LV relative (wall thickness/LV diastolic diameter ratio) > 0.41 = concentric geometry) over 20 years of follow up and to identify determinants of change in LV mass and geometry over that time interval. We used preliminary data on 1469 black and white men and women aged 43-55 years with complete data from the year 5 and 25 examinations for this analysis. Regression models had year 25 LV mass or relative wall thickness as the dependent variable and year 5 LV mass or relative wall thickness, age, gender, race, BMI, change in BMI, SBP, change in SBP, heart rate (HR), change in (HR), tobacco use, presence of diabetes, alcohol use, and physical activity score as independent variables. LV mass and relative wall thickness increased in each race/gender group (Table). Prevalence of normal LV mass/eccentric geometry decreased (84 to 63%) whereas concentric LV geometry increased (11 to 16%), as did LV hypertrophy (concentric (1 to 10%) and eccentric (3 to 11%) geometry). Significant determinants of year 25 LV mass/m2.7 were baseline LV mass, baseline and change in BMI, baseline and change in SBP, baseline and change in HR, presence of diabetes, and year 5 tobacco and/or alcohol use (r2 = 0.39). Significant determinants of year 25 LV wall thickness/diameter ratio were baseline ratio, black race, baseline and change in BMI, baseline and change in SBP, and presence of diabetes.(r2 = 0.08). We conclude prevalence of abnormal LV hypertrophy/geometry increased dramatically from young adulthood to middle age. Both young adult risk traits and change in these traits predicted change in LV mass/geometry. DM, for the first time, emerged in this analysis as a significant determinant.
|LV mass (g)||LV mass (g/m2.7)||Relative Wall Thickness|
|Black Men||Yr 5||176.2 (43.3)||37.4 (8.7)||0.37 (0.07)|
|n=262||Yr 25||216.5 (68.3)||46.1 (15.5)||0.39 (0.09)|
|White Men||Yr 5||166.7 (39.0)||35.1 (8.2)||0.34 (0.06)|
|n=362||Yr 25||198.8 (54.8)||42.0 (11.4)||0.35 (0.07)|
|Black Women||Yr 5||133.7 (37.6)||35.2 (9.7)||0.35 (0.06)|
|n=439||Yr 25||174.2 (53.9)||45.5 (14.0)||0.38 (0.08)|
|White Women||Yr 5||122.0 (29.8)||31.5 (7.9)||0.33 (0.05)|
|n=406||Yr 25||149.4 (42.7)||38.8 (11.1)||0.35 (0.08)|
values are mean (SD)
- © 2012 by American Heart Association, Inc.