Abstract MP010: Body Mass Index and Stroke Incidence in Japanese Elderly Men
Objective: To examine the association between body mass index (BMI) and incident stroke in Japanese elderly men.
Methods: A total of 4743 men and aged 65 years and over (mean age, 72 years) who had no history of stroke or myocardial infarction were followed up prospectively for 5.4 years. Stroke events were identified by accessing the Iwate Stroke Registry. Participants were classified into 6 groups according to BMI (kg/m2): less than 18.5, 18.5–20.9, 21.0–22.9, 23.0–24.9 (reference), 25.0–27.4, and 27.5 and over. Multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for ischemic stroke and hemorrhagic stroke according to BMI were estimated with adjustments for age, systolic blood pressure levels, total cholesterol levels, HDL cholesterol levels, HbA1c levels, current smoking, regular drinking and regular exercise using Cox’s regression.
Results: During the follow-up, 171 ischemic and 58 hemorrhagic strokes occurred. Compared to men with BMI of 23.0–24.9, men with BMI of 25.0–27.4 and BMI of 27.5 and over had 1.6- and 1.9-fold higher risks for ischemic stroke, respectively, and men with BMI of less than 18.5 and 18.5–21.9 had 4.1- and 2.5-fold higher risks for hemorrhagic stroke, respectively. (See Table)
Conclusion: The findings suggest that low BMI (less than 21) is an independent risk factor for hemorrhagic stroke and that high BMI (25 and over) is an independent risk factor for ischemic stroke in Japanese elderly men.
|BMI (kg/m2)||Less than 18.5||18.5–20.9||21.0–22.9||23.0–24.9||25.0–27.4||27.5 and over|
|No. of subjects||138||725||1126||1283||1018||453|
|No. of cases||3||29||41||33||42||23|
|HR (95% CI)||0.82 (0.25–2.72)||1.45 (0.86–2.43)||1.38 (0.87–2.19)||1 (reference)||1.58 (1.00–2.51)||1.92 (1.12–3.30)|
|No. of cases||4||15||12||10||11||6|
|HR (95% CI)||4.10 (1.24–13.6)||2.53 (1.10–5.82)||1.32 (0.57–3.08)||1 (reference)||1.40 (0.59–3.31)||1.62 (0.58–4.52)|
Incidence rate was defined as number of cases per 1000 person-years.
- © 2012 by American Heart Association, Inc.