Abstract MP008: Fatty Liver, Visceral Adipose Tissue and Atherosclerotic Calcification: The Jackson Heart Study
Background: Both fatty liver and abdominal visceral fat (VAT) are independently associated with cardiometabolic risk factors. We investigated whether fatty liver and VAT are jointly associated with coronary artery (CAC) or abdominal aortoiliac (AAC) calcification.
Methods: Jackson Heart Study (JHS) participants (n=2884, mean age 60 years, 65% women) underwent CT assessment for assessment of fatty liver, VAT, and CAC and AAC. Fatty liver was measured by liver attenuation (LA; low LA=high fatty liver). Cross-sectional associations between LA, VAT, CAC and AAC were examined in logistic regression models.
Results: LA (per 1-standard deviation [SD] decrement) was associated with CAC in the age-, sex-adjusted (OR 0.84, 95%CI 0.7–0.9, p=0.0001) and multivariable adjusted model including age, sex, smoking and alcohol, systolic blood pressure, treatments for hypertension, dyslipidemia and diabetes, total cholesterol and HDLC (OR 0.89, 95%CI 0.8–0.9, p=0.02). The association persisted for LA with CAC when additionally adjusted for VAT (OR 0.89, 95%CI 0.8–0.9, p=0.04) or body mass index (BMI) (OR 0.89, 95%CI 0.8–0.9, p=0.04). Abdominal VAT (per 1-SD increment) was associated with CAC in age-, sex-adjusted models (OR 1.27, 95%CI 1.2–1.4, p=0.0001), but the association was attenuated in the multivariable adjusted model (OR 1.10, 95%CI 0.9–1.2, p=0.09) or with additional adjustment for LA (p = 0.24) or BMI (p = 0.36). For AAC, the associations with LA and VAT were only present in the age-, sex-adjusted model. In addition, we did not observe interactions between LA and VAT for CAC (p=0.18) or AAC (p=0.24).
Conclusion: Fatty liver, but not VAT, is independently associated with atherosclerotic calcification in African American men and women and these observations persist after accounting for VAT or BMI.
- © 2012 by American Heart Association, Inc.