Abstract 9728: Arterial Stiffness is Associated with Carotid Atheromatosis in Hypertensive Patients (Campania Salute Network)
Background: Pulse pressure/stroke index (PP/SVi) is a validated measure of total arterial stiffness, but its relation to carotid atherosclerosis is unknown.
Methods: Data from 6209 hypertensive patients without prevalent cardiovascular disease (coronary heart disease, stroke, heart failure) in the Campania Salute Network underwent standard transthoracic echocardiography and carotid ultrasound. SVi was obtained by echocardiographic LV volumes computation; mean and maximal (max) carotid intima-media thickness (IMT) and the presence of plaques (≥1.3 mm) in the common and internal carotid arteries were assessed. The population was stratified into thirtiles of PP/SVi and analyzed using ANOVA.
Results: Increase from the lowest to the highest thirtiles of PP/SVi was associated with increasing age, progressively higher systolic and diastolic blood pressure (BP), higher total cholesterol and larger number of antihypertensive drugs (Table 1). The highest PP/SVi thirtile was also associated with higher max and mean IMT and higher prevalence of carotid plaques (Table1). In multivariate logistic regression analysis, compared to the lowest thirtiles, the prevalence of carotid plaque increased by 16% (95% confidence interval [CI] 1-34%, p<0.05) in the second PPSVi thirtile and by 33% (95% [CI] 15-55%, p<0.01) in the the highest PPSVi thirtile, independently of significant associations with diabetes mellitus, age, gender and total cholesterol.
Conclusion: In treated hypertensive patients included in the CampaniaSalute Network, higher PP/SVi is associated with carotid atherosclerosis independently of others confounders.
- © 2011 by American Heart Association, Inc.