Abstract 9634: Luteolin Inhibits the Wall Expansion of Aortic Anuerysm in Mice Model
Background: Luteolin is a food-derived flavonoid and its antioxidant, anti-inflammatory, and antiallergic functions are reported. Abdominal aortic aneurysm (AAA) is well-known disease that needs surgical repair before rupture of aortic wall. But little is known about the nonsurgical treatment for AAA.
Method: Female ApoE-/- mice at age 9 weeks were fed with chow containing 0.5% luteolin for 3 weeks and then were infused with angiotensin II (Ang II; 1.0 μ g/kg/min) for 4 weeks by an osmotic mini-pump. Control ApoE-/- mice and Ang II infused ApoE-/- mice with normal chow were also prepared for comparison. Their body weight, blood pressure and ultrasonographic diameter of abdominal aorta were measured every week until sacrifice at age 16 weeks.
Result: The body weight was similar in three groups (control 22.8±1.0 g, Ang ll with normal food group [Ang II +Luteolin-] 23.0±1.5 g, Ang II with luteolin food group [Ang II +Luteolin+] 23.4±1.7 g). Systolic blood pressure at sacrifice was extremely high in Ang II infused mice, but no difference between Ang II +Luteolin- and Ang II +Luteolin+ (control 94±4 mmHg, Ang II +Luteolin- 159±39 mmHg, Ang II +Luteolin+ 168±48 mmHg). The diameter of abdominal aorta at first was similar in three groups, and gradually increased with Ang II infusion. The max diameter at sacrifice was significantly smaller in Ang II +Luteolin+ than in Ang II +Luteolin- (1.1±0.2 mm vs. 1.9±0.5 mm, P<0.01). Histopathologic studies showed less frequent disruption of elastic media in Ang II +Luteolin+ than in Ang II +Luteolin-.
Conclusion: Luteolin inhibits the wall expansion of aorta in Ang ll-infused ApoE-/- mice model.
- © 2011 by American Heart Association, Inc.