Abstract 9569: Circulating Plasma Brain Natriuretic Peptide Predicts Longitudinal Change in Blood Pressure: The Jackson Heart Study
INTRODUCTION: Elevation in circulating brain natriuretic peptide (BNP) concentrations has been associated with hypertension in studies of non-Hispanic whites. However, the relation of plasma BNP concentration to progression in blood pressure (BP) category and to incident hypertension in African Americans is unknown.
HYPOTHESIS: We assessed the hypothesis that higher circulating BNP concentrations in non-hypertensive African Americans will be associated with change in BP category and incident hypertension.
METHODS: Our study population consisted of non-hypertensive participants of the Jackson Heart Study with BP, anthropometry and phlebotomy measures in both exam 1 (2000-04) and exam 2 (2005-08), and plasma measures of BNP in exam 1 only. We examined the relation of circulating BNP concentrations (categorical measures by quartile) to BP progression and to incident hypertension using multivariable logistic regression. The model adjusted for age, sex, BP categories (optimal; normal and high normal), systolic and diastolic BP, smoking, diabetes, body mass index, echo LV mass (all measured at baseline) and change in age between the two exam cycles.
RESULTS: The study population consisted of 1,158 participants (mean age 49±12 years, 59% women). The median follow-up period was 5.0± 0.8 years. We observed 38.1% of the participants progressed to a higher BP stage and 20.1% of the participants developed incident hypertension. In the multivariable regression model, elevated plasma BNP concentrations (based on highest quartile) were significantly and positively associated with BP progression [p=0.006; OR, 1.8; 95% CI (1.2, 2.6)] and marginally and positively associated with incident hypertension [p=0.06; OR, 1.3; 95% CI (0.8, 2.1)]. Categorical BNP was significantly and positively associated with both BP progression (p=0.006) and incident hypertension (p = 0.04).
CONCLUSION: In our community-based sample of middle-aged and elderly African Americans, higher plasma BNP concentrations were associated with increased risk of BP progression and incident hypertension in all participants.
- © 2011 by American Heart Association, Inc.