Abstract 9312: Prediction of Plasma Brain Natriuretic Peptide Levels Using ECG Gated 320 Slice CT in Subjects with Pulmonary Hypertension in Multiple Regression Models
Purpose: Plasma brain natriuretic peptide (BNP) levels integrates responses of cardiovascular and pulmonary systems. We tied to predict plasma BNP levels in subjects with pulmonary hypertension (PH) using 320 slice CT and right heart catheter (RHC) examinations.
Materials and Methods: 19 consecutive PH subjects (13 female, mean 53 yrs, 13 chronic pulmonary arterial thromboembolism and 6 primary PH) underwent retrospective ECG gated 320 slice CT (Aquilion one), and RHC. CT images were reconstructed every 5% from 0-95% of the R-R interval. We quantified right ventricular (RV) end-diastole (ED) (RVEDV) and end-systole (ES) volumes (RVESV), and RV ejection fraction (EF) (RVEF) and left ventricular (LV) end-diastole (ED) (LVEDV) and end-systole (ES) volumes (LVESV), and LV EF (LVEF) by CT, and mean pulmonary artery (PA) pressure (MPAP) and pulmonary vascular resistance (PVR) by RHC.
Results: Plasma BNP was 100.9±100.0pg/ml. RVEDV, RVESV, RVEF, LVEDV LVESV and LVEF by CT were 155.9±47.8ml, 88.3±49.7ml, 46.1±14.1%, 101.1±26.8ml, 31.7±9.6ml and 68.4±6.5%, respectively. MPAP and PAR on RHC were 37.9±10.7mmHg, and 570.3±263.4 dyne.sec.cm-5, respectively. Significant positive correlations were seen between plasma BNP levels and RVEDV (0.536, P<0.05), RVESV (0.645, P<0.01) on CT, MPAP (0.582, P<0.01), PVR (0.661, P<0.01) on RHC. Significant negative correlations were seen between plasma BNP levels and RVEF (-0.578, P=0.01), and LVEF (-0.674, P<0.01) on CT. All predictor variables using CT and RHC were analyzed and plasma BNP levels was predicted by multiple regression formula Y=-6.3X1+0.1X2+1.9X3-1.1X4+0.2X5+384 (Y, plasma BNP levels, X1=LVEF on CT, X2= PAR on RHC, X3=age (yrs), X4=RVEF on CT, X5= RVEDV on CT) (R2=0.646, p<0.05).
Conclusion: Plasma BNP levels can be predicted by 320 slice CT and RHC. LVEF and RVEF on CT might be negative predictors and PAR, MPAP on RHC and RVEDV and RVESV on CT might be positive predictors for estimating plasma BNP levels in subjects with PH.
- Pulmonary circulation
- Pulmonary hypertension
- Natriuretic peptide
- Ventricular function
- Computed tomography
- © 2011 by American Heart Association, Inc.