Abstract 9282: The Accumulation of Epicardial Adipose Tissue is an Independent Risk Factor for the Onset of Atrial Fibrillation
Introduction. Atrial fibrillation (AF) is associated with the structural and electrical remodeling of left atrium (LA) as well as the inflammation. The accumulation of epicardial adipose tissue (EAT) is now recognized as an inflammatory tissue, potentially contributing to the pathogenesis of AF. The developed multi-detector computed tomography (MDCT) is accurate for assessing coronary plaques characteristics as well as additional information for the tissue surrounding the heart, including chamber sizes and EAT volume.
Methods. This study consisted of 279 patients (176 men, 65 ± 10 years) who had no history of AF. These patients underwent MDCT for the evaluation of coronary artery disease. EAT volume, LA volume, and left ventricular (LV) mass were also measured by MDCT. Patients were divided into 3 groups according to EAT volume (lower tertile; mean 55 ml ranging 21 to 71 ml, middle tertile; mean 87 ml ranging 72 to 100 ml, upper tertile; mean 128 ml ranging 101 to 264 ml). The presence of the onset of AF during follow-up period was confirmed by the findings of electrocardiograms and/or Holter recordings.
Results. During follow-up of 3.3 ± 1.0 years, AF occurred in 17 (6.1%) patients. Patients with AF were more likely to be older, had significantly higher level of C-reactive protein, and had larger volumes of LV mass, LA and EAT on MDCT. The independent factors for the onset of AF were EAT volume and LA volume index (both p <0.001). The upper tertile of EAT volume had a significant increased risk for the occurrence of AF compared with the lower tertile (p <0.001), and middle tertile (p = 0.03).
Conclusions. We demonstrated that increased EAT volume, as estimated by MDCT, was independently associated with the occurrence of new onset AF.
- © 2011 by American Heart Association, Inc.