Abstract 9266: Heart Failure, Atrial Fibrillation and Neuromuscular Disorders Determine Mortality in Left Ventricular Noncompaction
Objectives and Background: The long-term prognosis of patients with left ventricular hypertrabeculation/noncompaction (LVHT) is assessed controversially. Aim of the study was to assess parameters influencing mortality and to compare the mortality of LVHT-patients with that of the Austrian general population.
Methods: Included were all patients in whom LVHT was diagnosed in the echocardiographic laboratory of the KA Rudolfstiftung between June 1995 and February 2011. They underwent a baseline cardiologic examination and were invited for a neurological investigation. Between January and February 2011, the patients were contacted by telephone and assessed if the patient was alive or not.
Results: LVHT was diagnosed in 162 patients (46 female, mean age 53±16 years) with a prevalence of 0.31%/year. Hundred-sixteen patients (72%) underwent a neurological investigation which revealed specific neuromuscular disorders (NMD) in 25, a NMD of unknown etiology in 74, and was normal in 17 patients. During a mean follow-up of 67 months, the mortality was 4.8%/years and the standardized mortality ratio 6.27 compared with the general Austrian population. By multivariate analysis, significant predictors for mortality were heart failure (Hazard-ratios 3.91, 4.48 and 5.37 for NYHA II, III and IV), atrial fibrillation (Hazard-ratios 3.26) and presence of NMD, either specific or of unknown etiology (Hazard-ratio 1.86).
Conclusion: Prognostic predictors in LVHT are heart failure, atrial fibrillation and NMD, which stresses the need for a neurologic investigation. Heart failure and atrial fibrillation should be treated consequently in LVHT.
- © 2011 by American Heart Association, Inc.