Abstract 8891: Serum 25-Hydroxyvitamin D3 Level is Correlated with Cardiometabolic Risk But Not Increased Carotid Artery Intima-Media Thickness in High-Risk Children
Background: Some literature supports a link between cardiometabolic risk and vitamin D deficiency among adolescents. Currently, there are no studies examining the effects of vitamin D deficiency on the vasculature in high-risk children.
Purpose: To determine whether there is a correlation between vitamin D levels, cardiometabolic risk, and carotid artery intima-media thickness (CIMT), a marker of subclinical atherosclerosis, among high-risk children.
Methods: Serum 25-hydroxyvitamin D3 levels were compared to CIMT in 74 high-risk children with multiple modifiable atherosclerosis-promoting risk factors. Vitamin D was categorized into three levels (Insufficient < 20 ngm/mL, Borderline 20 to 30 ngm/mL, and Sufficient > 30 ngm/mL). Modifiable atherosclerosis-promoting risk factors that were included were BMI Z score, Systolic blood pressure (SBP), Total cholesterol (TC), Triglyceride (TG), High density lipoprotein cholesterol (HDL C), Insulin, & Tobacco smoke exposure history.
Results: Age was 13.7 ± 3.1 years (6-22 years); 45 % Male; 62% White. Vitamin D was 23.1 ± 9.4 ngm/mL (range 6-63 ngm/ml). Vitamin D levels were Insufficient in 20%, Borderline in 57% and Sufficient in 23%. BMI Z score 1.4 ± 1.1, SBP 117 ± 10 mmHg, TC 215 ± 45 mg/dL, TG 195 ± 302 mg/dL, HDL C 46 ± 60, Insulin 17 ± 22 uIU/mL, Tobacco smoke exposure history 30%. Mean modifiable atherosclerosis promoting risk factor score was 3.3 ± 1.6. CIMT mean was 0.48 ± 0.04 mm; CIMT maximum was 0.54 ± 0.06 mm. There was an inverse correlation between vitamin D levels and risk factor score (Figure). Multivariative analysis adjusting for risk factor score did not confirm any association between vitamin D and mean (p= 0.23) or maximum (p= 0.40) CIMT.
Conclusion: Among high-risk children, vitamin D levels are inversely correlated to cardiometabolic risk but there was no association with CIMT.
- © 2011 by American Heart Association, Inc.