Abstract 8699: Validation of Speckle Tracking Echocardiography in Assessment of Left Atrial Volume and Function: a Comparative Study with Three-dimensional Computed Tomography
Background: Noninvasive assessment of left atrial (LA) function was limited by a lack of a suitable method and automated LA border detection with acoustic quantification was expected to facilitate the assessment of LA volume and function. Speckle tracking echocardiography (STE) (ACUSON sequoia 512, Siemens) which can detect LA border and provide time-LA volume curve automatically has been recently used to assess LA function. Thus, the aim of this study was to validate STE in assessment of LA volume (LAV) and function compared with 3-dimensional computed tomography (CT).
Methods: Maximum (max.) and minimum (min.) LAV measured using Simpson's rule in apical 4-chamber view and LA total emptying function (EF) were compared to manual tracing method in 66 subjects in a blind way and were compared to CT with 64 rows in 20 subjects undergoing catheter ablation. Interobserver variability of max. LAV and min. LAV and LA total EF by STE in 66 subjects was determined by 2 observers in a blind way. Intraobserver variability of those parameters by STE in 66 subjects was determined by one observer with 7 days interval. LA total EF was defined as (max. LAV - min. LAV) / max. LAV.
Results: LAV and LA total EF were easily and quickly obtained by STE. There was a good correlation between STE and manual tracing method in max. LAV, min. LAV and LA total EF (r=0.98, r=0.98 and r=0.95, respectively, p<0.001). There was also a good correlation between STE and CT in those parameters (r=0.95, r=0.96 and r=0.97, respectively, p<0.001). Bland-Altman analysis between STE and CT in those parameters revealed an excellent correlation. The interobserver correlation coefficient and relative differences in max. and min. LAV and LA total EF by STE were 0.98 and 0.94±6.8%, 0.99 and 8.0±11% and 0.99 and 2.2±15.9%, respectively. The intraobserver correlation coefficient and relative differences in those were 0.98 and 2.6±6.2%, 0.98 and 8.1±11.6% and 0.90 and 4.0±12.4%, respectively.
Conclusion: Max. LAV, min. LAV and LA total EF determined from time-LA volume curve by STE exhibited a good agreement with those determined by the manual and CT method. STE had an excellent feasibility as a noninvasive estimation of LA and may be no less useful in the routine clinical setting for the evaluation of LA volume and function than CT.
- © 2011 by American Heart Association, Inc.