Abstract 8634: Serial Changes of Neointimal Coverage Conditions and Characteristics are different between Sirolimus-Eluting Stents and Paclitaxel-Eluting Stents Implantation: Follow-Up Optical Coherence Tomography Study
Background: The long-term detailed changes of neointima coverage and characteristics in Sirolimus-eluting stent(SES) and Paclitaxel-eluting stent(PES) remains to be clarified.
Methods: Of 18 SES (14 patients) and 13 PES (12 patients), OCT was used to visualize 2486 and 1361 stent-struts at 8 months after implantation 2199 and 1309 stent-struts at 20 months after respectively. The OCT parameters, including incidence of uncovered struts and malapposed struts and neiointimal hyperplasia thickness (NIH thickness) and NIH% were compared between SES and PES and between 8 months after and 20 months after for SES and PES.,The neointimal charecteristics were classified into 3 groups:high without PLIA(high density neointima without peri-strut low-intensity area(PLIA),high with PLIA and non-high .PLIA was defined as a region around stent struts with a homogeneous,lower intensity appearance
Results: Uncovered ratio and malapposed ratio was significantly higher in SES than in PES both at both follow-up. NIH thickness and %NIH was higher in PES than in SES at both follow-up. Uncovered ratio significantly decreased in SES from 8months to 20months after, and in PES nonsiginificantly decreased . Malapposed ratio nonsignificantly decreased in both groups. NIH% and NIH thickness significantly increased in SES ,but NIH% and NIH thickness significantly decreased in PES from 8months after to 20months after. High signal neointima accounts for more than 90% in both groups.However it decreased in SES ,while increased in PES. High with PLIA nonsignificantly increased in SES ,but decreased in PES. Non-high signal neointima decreased both in SES and in PES.(Table)
Conclusions: Uncovered struts and malapposed struts gradually alleviated in both SES and PES while neointimal hyperplasia condition and characteristics showed different patters; increasing in SES but decreasing in PES.
- © 2011 by American Heart Association, Inc.