Abstract 8622: Transmural Dispersion of Repolarization in Febrile Children with Kawasaki Disease
Introduction: The instability of myocardial repolarization is generally mediated by myocardial failure. We assessed the hypothesis that transmural dispersion of repolarization is increased in the inflamed myocardium in patients with acute-phase Kawasaki disease.
Method: Consecutive 25 infants (M:F = 15:10 ) with Kawasaki disease aged 2.6 ± 2.2 years and 25 age-matched control infants were included. RR interval, QT interval and Tp-e time (CM5 lead) were calculated using analysis software (Acqknowledge Ver. 3.9, Biopac Systems Inc. CA, USA). Tp-e time was corrected by Fridericia equation (Tp-eC). These parameters were compared in the acute phase (6.9 ± 3.0 days after onset) and recovery phase (23.0 ± 13.3 days after onset) or control. The relationship between Tp-e/QT, Tp-eC and C reactive protein, body temperature on admission were evaluated by regression analysis.
Results: 1) The Tp-e/QT in the acute phase were significantly higher than that in the recovery phase (Mean ± SD: 0.248 ± 0.055 vs 0.215 ± 0.022, p<0.05 ) and control group (0.220 ± 0.025, p<0.005). 2) The Tp-eC in the acute phase was significantly higher than that in the recovery phase (89.99 ± 16.86 vs 82.11 ± 7.45, p<0.05) and control group (80.02 ± 10.46, p<0.01). 3) In acute phase, significant positive correlation was observed between Tp-e/QT and C reactive protein or body temperature (r = 0.677 and 0.672, respectively). Further, between Tp-eC and C reactive protein or body temperature (r = 0.482 and 0.583, respectively).
Conclusions: Transmural dispersion of repolarization assessed by Tp-e/QT and Tp-eC was increased in the acute phase of Kawasaki disease, which exhibits the sub-clinical lability of ventricular repolarization. These repolarization properties of the myocardium were considered a useful indicator to assess arrhythmogenesis in patients with Kawasaki disease.
- © 2011 by American Heart Association, Inc.