Abstract 8454: High Resolution Echocardiography Can Detect Myocardial Damage in the Right Ventricle: A Feasibility Study
Background: The unique geometry and thinner walls of the right ventricle (RV) present a challenge for strain imaging.
Methods: We studied 5 freshly harvested pig hearts. Each heart was mounted in a water bath for ultrasound imaging. A pulsatile pump was attached to the RV through a latex balloon inserted into the cavity with a fixed volume of water. Pulsatile flow into the RV cavity was generated by delivering 6 calibrated stroke volumes (15-40 ml) at 60 beats/min. Cardiac motion was scanned with 10S probe to acquire 2D short axis views on a GE Vivid 7 Dimensions ultrasound system at frame rates of 80-100fps. After baseline imaging, we injected 1-2ml of glutaraldehyde into the RV free wall to simulate myocardial fibrosis or scarring. The study was repeated at the same stroke volumes. Images were exported to EchoPac PC for analysis of circumferential and radial strain using speckle tracking by three observers.
Results: Incremental increases in stroke volumes resulted in well correlated increases in stretching and thinning of RV walls, increased circumferential strain (r=0.87) and decreased radial strain (r=0.79). At each stroke volume, the modeled RV scar showed significantly diminished circumferential and radial strain deformation, with high reproducibility among observers (r=0.82).
Conclusions: Speckle tracking based determination of cardiac mechanics provides a robust method for evaluation of altered function in the “infarcted” segments of the RV.
- © 2011 by American Heart Association, Inc.