Abstract 8446: Human Fetal Cardiac Ejection Fraction in Normal and Diabetic Pregnancy Assessed by Matrix 3D/4D Echocardiography
Background: Diabetic pregnancy carries higher risk of fetal development abnormality compared to normal pregnancy. Therefore, fetal growth should be monitored during diabetic pregnancy. We used a 4D matrix method to evaluate whether maternal diabetes could affect fetal heart function.
Methods: 24 women 18.0-33.1 weeks gestational age (mean 23.6 ± 4.5 weeks) were included: 12 insulin-dependent diabetic pregnant patients and 12 healthy pregnant women with the same gestational ages. A Philips iE33 ultrasound system with an X7-2 matrix array transducer was used. 4D volumes were acquired from the fetuses with an external heart rate simulator. 4D data was analyzed by QLab 6.2 software (Philips). End-systolic and end-diastolic volumes of left and right ventricles (LV, RV) and ejection fraction (EF) derived for each individual were calculated semi-automatically, and maternal blood HbA1C were recorded.
Results: Blood HbA1C levels of the diabetic group were 6.99±1.10%, which was higher than the normal level (5.0%). LV EF of the fetuses with diabetic mothers ranged from 52.4% to 85.9% (mean 70.2 ± 11.2%), and 52.3% to 83.3% (mean 71.5 ± 10.5%) for the control group. No significant difference was shown between LV EFs (P = 0.4029). However, RV EF was 55.3% to 85.1% (mean 66.8 ± 9.9%) in the diabetic group, compared to 64.9% to 87.1%(mean 77.2 ± 7.3%) for the control group (P = 0.0108).
Conclusions: LV EF of human fetuses of diabetic mothers was normal, but RV EF of the diabetic pregnancy group was lower.
- © 2011 by American Heart Association, Inc.