Abstract 8425: Fetal Cardiac Ventricular Volume and Mass Derived from Spatio-Temporal Image Correlation
Background: Fetal cardiac assessment is usually performed qualitatively. Functional and longitudinal studies of abnormal fetuses would benefit from reproducible quantitative cardiac measurements. We used spatio-temporal image correlation (STIC) to measure left and right ventricular (LV, RV) volumes and masses in normal and structurally abnormal fetal hearts.
Methods: 44 normal fetuses and 7 with structural heart disease (dextrocardia, DORV, d-TGA, HLHS, pulmonary stenosis PS, VSD) at gestational ages between 16 and 38 completed weeks were included. STIC volumes were acquired and analyzed in end-diastole and end-systole according to an established and validated method.
Results: Measurements were possible in all fetuses. Ventricular volumes and masses increased with gestation. In fetal DORV, HLHS and PS, RV volumes were increased, in DORV and PS, RV mass was increased. In normal hearts, RV mass was 20% higher than LV mass throughout gestation, but the ejection fraction was slightly higher in the LV.
Conclusions: Using STIC the human fetal heart can be studied quantitatively, taking into account the complex geometry especially related to the right ventricle.
- © 2011 by American Heart Association, Inc.