Abstract 8322: Obesity-Related Alteration of Arterial Compliance Associated with Concentric Left Ventricular Hypertrophy Begins to Appear in Childhood
Background: Obesity is associated with worsening arterial compliance, but there is little information when arterial functional change begins to appear. The ratio of pulse pressure/stroke volume is a novel index for arterial compliance. The purpose of this study is to assess the relationship between body mass index (BMI) and this index and to investigate their relations to left ventricular (LV) geometry and function from childhood to adolescence.
Methods: Echocardiography with tissue Doppler imaging was performed in 389 healthy subjects. Subjects were divided into 3 age groups: pre-school children group, 4 to 6 years (5±1 years, n = 125); school children group, 7 to 12 years (9±3 years, n = 176); and adolescents group, 13 to 20 years (15± 3 years, n = 88). Left ventricular (LV) end-diastolic volume and LV mass were measured and LV mass-to-volume ratio was calculated. Stroke volume (SV) was calculated using aortic diameter and pulsed Doppler velocity profile. SV was indexed for body surface area (SVI). Total arterial compliance (Ca) was estimated by the ratio of pulse pressure/SVI. Tissue Doppler-derived myocardial performance index (MPI) was calculated. Quantitative B-mode ultrasound scans were used to measure intima-media thickness (IMT) of the common carotid artery.
Results: There was no significant relationship between BMI and Ca in the pre-school children group. However, in the school children and adolescents groups, weak but significant correlations between Ca and BMI were found (r = 0.29 and o.25, respectively, p < 0.01). Within each group, LV mass-to-volume ratio increased significantly with BMI. Ca did not correlate with LV mass-to-volume ratio in the pre-school children group, however, increased Ca correlated significantly with increased LV mass-to-volume ratio in the school and adolescents groups (r = 0.17 and 0.23, respectively, p < 0.01). There were weak but significant relationships between Ca and MPI and carotid IMT (r = 0.25 and 0.24, respectively, p < 0.01) in the adolescents group.
Conclusions: Obesity-related changes in arterial compliance and LV geometry and function begin to appear in younger school children. Our findings suggest that primary prevention programs should be initiated in early childhood.
- © 2011 by American Heart Association, Inc.