Abstract 8303: Silica-Gold Nanoparticles and Mesenchymal Stem Cells versus Composite Ferro-Magnetic Approach for Management of Atherosclerotic Plaque and Artery Remodeling
Background. Some modern angioplasty techniques generally just manipulate the form of the plaque and have some clinical and technical restrictions, relatively high complication rate and restenosis risk.
Methods. A total of 180 patients with stable angina were randomly assigned to the three groups (60 patients into nanogroup with the use of 60/15-70/40 nm silica-gold nanoparticles (NPs) transplanted by endoscopic cardiac surgery in the composition of bioengineered on-artery patch grown on the basis of biopolymeric scaffold and host circulating CD45-CD34-CD73+CD105+ progenitor cells, 60 - into ferro-magnetic group with 60/15-70/40 nm silica-gold iron-bearing NPs with delivery in hand of magnetic navigation system, and 60 - in sirolimus-eluting stenting control). NPs were detonated with near-infrared laser irradiation on day 3 under the drug antithrombotic protection. We have used a modified method for the preparation of NPs as described by Lee (2008) and Deng H (2005). Studied proximal left anterior descending arteries were observed by 30 MHz intravascular ultrasound (IVUS).
Results. A change of the plaque volume (PV, mm3) as-intervened/ in 9 months in groups were −24.3/ −66.8%, −29.5/ −42.3% and −11.4/ +4.3% (p<0.01) respectively. An impact over the non-organic part of the plaque (mineral deposits, calcium necrotic core) was predominated in nanogroup (−43.4% vs −12.1% and +3.7% respectively, p<0.005). While first 4 weeks, 3/60 (5%), 2/60 (3.3%), 7/60 (11.7%) cases of acute atherothrombosis were revealed in groups respectively (p<0.01). Restenosis confirmed in 3 (5%) patients of stenting group only. Event free survival (cardiac death, recurrent symptoms, MI) in 9 mns was 95, 91.7 and 85% in groups respectively (p<0.01). Coronary flow-mediated vasodilation was observed after hyperemia and injection of nitroglycerine (+10.2 and +16.6%, +8.2 and +9.6%, +8.1 and +9.8% in groups respectively, p<0.05).
Conclusion. Nanoburning is the novel promising technique to demolish and melt the plaque especially in combination with stem cell technologies challenging functional restoration of the vessel. Plasmonics is the high-effective and safe alternative to stenting for angioplasty.
- Stem cell and atherosclerosis
- Acute coronary syndromes
- New technology
- Cardiovascular disease
- © 2011 by American Heart Association, Inc.