Abstract 8160: Risk Factors For Hospital Mortality And Morbidity Following The Norwood Procedure: Results From The Multicenter Single Ventricle Reconstruction Trial
BACKGROUND We sought to identify risk factors for mortality and morbidity during the Norwood hospitalization in a large prospective cohort of newborns with hypoplastic left heart syndrome and variants enrolled in the Single Ventricle Reconstruction trial.
METHODS Potential predictors for outcome included patient and procedure related variables and center/surgeon volumes. Outcome variables occurring during the Norwood procedure and prior to hospital discharge or stage 2 surgery included: mortality, end-organ complications, length of ventilation and hospital length of stay (LOS). Variables with univariate p ≤ .2 were used as candidate predictors for multivariable regression modeling (p < .05, significant). A reliability estimate of greater than 50% obtained by bootstrapping was required for terms to remain in the mortality model.
RESULTS Analysis included 549 patients from 15 centers. Hospital mortality was 16% at a median of 16 (1 - 149) days after the Norwood procedure. Shunt type at the end of the Norwood procedure was not a significant risk factor for mortality during the Norwood hospitalization. Independent risk factors for mortality (n=88), renal failure (n=46), sepsis (n=93), length of ventilation among survivors (7 days, range 1 - 270) and hospital LOS among survivors (24 days, range 6 - 270) are shown in the Table.
CONCLUSION Innate patient factors, pre-operative condition and lower center volume impact post-operative mortality and morbidity during the Norwood hospitalization.
- © 2011 by American Heart Association, Inc.