Abstract 8124: Effect of Strong Lipophilic Statin Therapy on Left Atrial Structure and Function Assessed by Speckle Tracking Echocardiography in Elderly Hypertensive Patients
Background: Prevention of the processes of left atrial (LA) remodeling associated with atrial fibrillation and heart failure especially in elderly hypertensive patients (HT) may have a major public health impact. Statins may attenuate cardiac hypertrophy by inhibition of intracellular signaling molecules such as Rac 1 and may be associated with lower mortality in patients with heart failure. We assessed the hypothesis that strong lipophilic statin (pitavastatin) has a beneficial effect on LA structure and function in elderly hypertensive patients by preventing left ventricular (LV) hypertrophy through pleiotropic effect.
Methods: LA phasic volume by Simpson's rule and LA total, passive and active emptying function (EF), and LA strain rate (SR) at systole, early diastole and atrial contraction were measured in apical 4-chamber view by speckle tracking method that can provide time-LA volume curve automatically and promptly among three groups; HT with statin group was consisted of hypertensive patients with hyperlipidemia treated with statin for more than two years (n=68, age 74±4, 32 men), HT without statin group was age-matched HT but without hyperlipidemia and statin (n=68, age 74±4, 40 men) and control group was age-matched normal subjects (n=66, age 74±6, 29 men). LV mass, LV ejection fraction and E/e’ as a diastolic function were measured.
Results: LA volume and function in HT with statin were more preserved than HT without statin despite no difference in LDL cholesterol, blood pressure and antihypertensive drug use. SR at systole and atrial contraction in HT with statin was significantly increased associated with dilation of LA. LA volume and function in HT with statin were comparable to control (Table).
Conclusion: Pitavastatin had a beneficial effect on LA structure and function associated with preserved diastolic function through pleiotropic effects in elderly hypertensive patients.
- © 2011 by American Heart Association, Inc.