Protease-Activated Receptors in Hemostasis, Thrombosis and Beyond
Protease-activated receptors (PARs) provide a mechanism by which thrombin and related proteases can regulate the behavior of platelets and other cells. Overall, the coagulation cascade and PARs together provide an elegant system that links mechanical information in the form of disruption of vascular integrity to appropriate cellular responses involved in hemostasis, inflammation, repair, and even pain perception. This talk will focus on lessons from animal models regarding the roles of PARs in hemostasis and thrombosis and how these lessons might and might not relate to the pathophysiology of myocardial infarction in humans and ongoing trials of PAR1 antagonists for secondary prevention of the same. Recent work that reveals unexpected roles for PARs outside the context of response to injury –– specifically in vascular and neural development in vertebrate embryos –– will be also be briefly summarized.
- © 2011 by American Heart Association, Inc.